Watch How to Change Your Mind

Mescaline, the psychoactive molecule in San Pedro and peyote cacti, a sacred medicine that Native Americans have had to fight for the right to use.

Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to become legalized, thanks to ionate advocates.

Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring their intense effects.

From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.